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You can set up a good grid from the start of a new document in Indesign. When the New Document pops up, you can set the number of columns in your document. I tend to use either 3 or 5 columns. You can use as many as you want. I tend to try to keep it simple and to the point. This is a great base for setting up your document to be clean and well organized.

You can have an image take up 2 columns, while you could have 2 columns of text under it. Then, the other 3 columns could have objects aligned to them, or to fit those constraints. The grid will help you to align your different elements and keep the document clean and structured. The example shown uses the default margins, but if you want the grid to span the entire size of the document for bleed purposes, then simple set the margins to 0.